August 5, 2020

UA scientists investigate connection between Alzheimer's and Down syndrome

The team is developing new ways to look at protein interaction in the human brain.

Alzheimer's - Down Tangled proteins in the Alzheimer's affected brain harm communication between nerve cells.
National Institute on Aging, NIH

Scientists at the University of Arizona are looking deeper into the connection between Alzheimer's disease and Down syndrome.

They are developing technology that will give researchers clues to the exact relationship between a pair of proteins shared by the two conditions. UA biochemistry professor Wolfgang Peti thinks it could lead to a better understanding and treatment of several neurological disorders.

"Basically, what we are doing is we are painting a picture of it," he said. "When you have a picture in front of you, you can let your imagination go crazy and find ways to influence that interaction."

Peti and fellow UA professor Rebecca Page collaborated with a team of researchers investigating the proteins Calcineurin and RCAN1. Peti says scientists can use their findings to develop drugs and other treatment options. The research team's work was recently published in the journal Science Advances.

By posting comments, you agree to our
AZPM encourages comments, but comments that contain profanity, unrelated information, threats, libel, defamatory statements, obscenities, pornography or that violate the law are not allowed. Comments that promote commercial products or services are not allowed. Comments in violation of this policy will be removed. Continued posting of comments that violate this policy will result in the commenter being banned from the site.

By submitting your comments, you hereby give AZPM the right to post your comments and potentially use them in any other form of media operated by this institution.
Arizona Public Media is a service of the University of Arizona and our broadcast stations are licensed to the Arizona Board of Regents who hold the trademarks for Arizona Public Media and AZPM. We respectfully acknowledge the University of Arizona is on the land and territories of Indigenous peoples.
The University of Arizona